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The prodrugs have been found to possess reduced cytotoxicity compared to the parent moieties, and are excellent substrates for the enzyme, exhibiting cytotoxicity selectively in the presence of the enzyme.
The results obtained from the present study reveal structural/functional group sensitivity for the tyrosinase inhibitory activity of stilbenoid moieties and are expected to be very helpful for the design and synthesis of novel, selective and effective tyrosinase inhibitors.
The Ra, Rb, and Y 'atoms' are actually placeholders to define larger moieties and are not really elements.
C-type lectins recognise carbohydrate moieties and are often induced by proinflammatory signals [ 58, 69], to regulate a variety of immune processes including the complement system [ 70- 72].
In plants, phenylopropanoids can be acceptors of sugar moieties and are often converted to their glycoconjugates, which are then accumulated and compartmentalized in vacuoles [ 13].
These compounds may be activated versions of the native form as a result of phase I metabolism, or phase II conjugated metabolites with glucose, sulphate or amino acid moieties, and are defined as 'modified mycotoxins' [ 12].
Similar(53)
This idea is consistent with the relatively long distance between the two moieties, and is also supported by the calculated interaction energy ∆E between the lone pairs of the sulfur atom and the LUMO of the pyrimidone moiety.
DHE preferentially detects superoxide moieties and was used to assess superoxide levels.
This constitutes a characteristic feature of phosphonium moieties and was termed a-effect.
The stilbamidine derivative furamidine 36 contains two amidine moieties and is specific for PRMT1 with an IC50 of 9.4 μM.
These compounds incorporate various C5′-moieties and are shown to have different kcat/Km values compared with the natural MTAP substrate (MTA).
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