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MACCS key fingerprints were generated for the SB compounds using the MOE software package (CCG, Inc .. Cluster composition was then also calculated using the Fingerprint Cluster method in MOE with a 0.85 similarity threshold and Tanimoto similarity metric.
NIE will also present MOE with a list of courses that NIE faculty think is important and relevant for teachers and request for MOE endorsement to fund teachers to attend the courses.
This was computed in MOE with a solvent probe radius of 1.4 Å.
Static MoE for the population of sheets was estimated by multiplying the dynamic MoE with a factor of 0.868.
He's got a missing tooth!", but the scenes that had Moe with a missing tooth in them were still reanimated.
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Roar Moe walks with a rangy stride to the dock on the beautiful curved harbour of his island, Little Færøy, greeting the boat's crew with a familiar shout.
Heterozygous mice contain approximately 12 genomic copies of the transgene, which are expressed in mature olfactory neurons throughout the MOE with the exception of a band of neurons near zone 2 (see Figure 5B), a pattern that was reproducibly observed in all individuals examined (n = 8).
Dischinger's evaluation of the change in concrete MOE with time was based on a creep coefficient determined from laboratory tests.
Uniform 2′-MOE ASOs with a phosphorothioate backbone were synthesized with an Applied Biosystems 380B automated DNA synthesizer (Applied Biosystems, Foster City, CA, USA) as described previously (29).
2′-MOE oligonucleotides with a phosphorothioate backbone and all 5-methylcytosines were synthesized and purified as described (Hua et al, 2010).
In preclinical mouse models, the comparison with of MOE-ASO with a third-generation LNA ASO showed increased antitumour activity of LNA ASO but also severe hepatotoxicity with increased levels of aminotransferases (ALT, AST) and large swelling of liver and spleen (Swayze et al, 2007).
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