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In addition, the (tensile) elastic modulus of prion and non-prion fibrils is almost independent of pulling speed for its range of 0.001 to 0.05 Å/ps.

In addition, we measured the elastic modulus of prion and non-prion fibrils, respectively, which were pulled along the fibril axis.

As our previous study [19] reports that the axial elastic modulus of prion fibril is larger than that of non-prion fibril, we study the tensile deformation behaviors of prion and non-prion fibrils using SMD simulations.

It is found that the axial elastic modulus of prion fibril is larger than that of non-prion fibril, whereas the mechanical toughness and strength of prion fibril are smaller than those of non-prion fibril.

The black dashed region of the stress-strain curve is shown in the right panel Fig. 3 Elastic modulus of prion and non-prion fibrils as a function of pulling speed.

Our simulation results show that the elastic modulus of prion fibril, which is formed based on left-handed β-helical structure, is larger than that of non-prion fibril constructed based on right-handed β-helix.

Similar(54)

The values of elastic modulus of both prion and non-prion fibrils are comparable to the elastic modulus of Aβ fibrils (i.e., ~15 GPa) [55] measured from SMD simulations.

The elastic modulus of non-prion and prion fibrils is measured as ~13 and ~18 GPa, respectively, when these fibrils were extended with a pulling speed in a range of 0.001 to 0.05 Å/ps (Fig. 3).

The urinary prion seems to be an excellent marker for the progression of prion diseases, Dr. Gabizon said.

Figure 2 shows the stress-strain curves of prion and non-prion fibrils, respectively.

Here, we note that the length of prion and non-prion fibrils is measured as 8.2 and 8.4 nm, respectively.

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