A promising strategy is seen in an efficient modularisation that reduces biological systems to a limited set of functional modules with well-characterised interfaces.
Motivated by statistical evidence, suggesting a hierarchical modular architecture in this network, we identified eight modules with well-defined physiological functions.
The identification of the overlapping modules of a high-confidence yeast protein-protein interaction network [25] resulted in a number of modules with well-known functions (Figure 6A and Figure S1.14 in the Electronic Supplementary Material S1).
Multiple miRNAs are assigned as high-scoring candidate regulators for several modules, together with well-known transcription factors or signal transducers.
In contrast, the inclusion of σ factors in the B. subtilis TRN generated cohesive modules associated with well-defined physiological functions and cell processes that are characteristic of this model organism.
We obtained a modular partitioning of protein structures with the modules correlating well with experimental evidence of early folding units or "foldons".
We have organized the curriculum into modules, with didactic as well as experiential components, utilizing a variety of educational venues, some new and some typically found within the existing framework of an internal medicine residency curriculum.
Our analysis of the yeast Sacchromyces cerevisiae suggests that most of the detected modules correspond to one or more experimentally functional modules and half of these annotated modules match well with experimentally determined protein complexes.
We had demonstrated that these modules correlated well with early folding units or foldons.
The GSEA analysis in Figure 2 shows that the expression patterns of genes in these two modules correlate well with our current knowledge about the development potential of early embryonic cells: a gradual loss of stemness and a concomitant diversity of cell types.
The apparent outlier, A. nidulans, shares gene modules with both groups as well as local rearrangements of modules, giving rise to a unique cluster configuration that is intermediate in size to partial and full gene clusters.
