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We identified 4 microbial community modules with significant differences between groups over time.
Strikingly, of the 350 modules with significant recurrence, 162 stemness-on and 62 stemness-off modules had significant cell-diversity and specificity scores (Figure 3).
The most remarkable observation is that the proportion of co-expression modules with significant network parameters is higher than the equivalent values in the signatures and more similar to the corresponding values observed for GO, KEGG or Biocarta (see Table 3).
Modules with significant correlations (Bonferroni corrected P-value ≤ 0.05) were considered age dependent.
Modules with significant involvement in transcriptional regulation are targeted by a small set of microRNAs.
We further partition this network into gene modules and identify the modules with significant association with either SCLC or NSCLC in terms of gene expression variation.
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The female amygdala (F-Amy) had a turquoise module with significant correlation with the Walking and Still parameters.
If modularity influences morphological evolution, one would expect differences in the morphological disparity of the "strong modules", those with significant within-module trait correlations in most taxa, and the "weak modules", those with mean within-module trait correlations that are significant in some examined species, but not significant in most of the taxa in each clade.
With regard to physical HQoL, patients in module 0 reported a significantly higher level compared to the patients in all other modules, with no significant difference between modules 1, 2 and 3 (F 3,541) = 8.45, p < 0.001; see Table 3).
We obtained 47 functional modules with a significant r value.
This demonstrates the power of Wigwams to select modules with statistically significant dependent co-expression.
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