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Small pilot-scale modules with relatively large membrane areas (110 330 cm2) were additionally tested.
ROI-based These are the modules with relatively high co-expression profiles between ROIs, i.e., (overline{z}_{text{ roi }}(mathbf {X})) is ranked in the top 20%% of all the (overline{z}_{text{ roi }}) scores.
Gene-based These are the modules with relatively high co-expression profiles between genes, i.e., (overline{z}_{text{ gene }}(mathbf {X})) is ranked in the top 20%% of all the (overline{z}_{text{ gene }}) scores.
Thus, in this work, we focus on the analysis of the following three types of GS BC modules with top z-statistics: 1. Gene-based These are the modules with relatively high co-expression profiles between genes, i.e., (overline{z}_{text{ gene }}(mathbf {X})) is ranked in the top 20%% of all the (overline{z}_{text{ gene }}) scores.
As illustrated in Figure 5, the histograph of the maximal similarity showed that more than half of the pairs share less than 15% genes, and there are only four pairs of modules with relatively high between-species similarity.
In its current form, ICM is able to detect modules with relatively large number of missing links.
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It has been decided to go along with DCMD modules with a relatively short channel length.
Proteins accession numbers and other characteristics are tabulated in Additional file 2. HG = homogalacturonan, RGI = rhamnogalacturonan I; GlcNAc = N-acetylglucosamine. P. parasitica proteins with multiple CAZyme modules were relatively rare, with only 50 of the 431 proteins (i.e., 11.6%) having more than one module.
Specifically, ∼1000 cis regulatory module (CRM) GAL4 lines with relatively sparse neuronal expression patterns (Jenett et al., 2012) were crossed to LexAop2-FLP; fru LexA, UAS>stop>myr::GFP to restrict expression of GFP to those neurons that express both GAL4 and fru LexA.
The HS-CC data illustrate that relatively sophisticated module details can be detected with relatively modest sample sizes.
The assumption of LO-refinement is that the macromolecular complex can be treated as a combination of multiple modules, with each module exhibiting a relatively rigid conformation within our interested resolution.
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