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A strengthened biosynthetic pathway of lovastatin was constructed through the assembly of three modules with increasing module-specific antibiotic stress in the methylotrophic yeast P. pastoris.
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This conclusion is supported by the fact that with increasing number of operated modules the quantity of module combinations decreases and thus the scattering declines.
The overall electrical efficiency of the photovoltaic (PV) module can be increased by reducing the temperature of the PV module by withdrawing the thermal energy associated with the PV module.
Researchers presented their results for new solar cells and modules with increased performance and lower manufacturing costs.
In vivo and in silico characterization of the variants demonstrated that we obtained psd modules with increased degradation rate and higher dark/light ratio.
Modules with increased intra-modular connectivity suggest genes involved in similar process, however, in terms of significance, the modules (or differentiability) on the intra-modular connectivity cannot be considered without global connectivity.
Compared to normal breast epithelium as the healthy reference phenotypic state, the only modules with increased heterogeneity in all of the breast cancer subtypes are nucleosome assembly and mammary morphogenesis.
For example, genes involved in the canonical pathway 'GABA-ergic signaling' (Slc32a1, Gabrg1 and Gad1) are closely correlated in the Red module, with increased expression levels in the amygdala.
Top modules were defined as those having the highest positive or negative correlation between GS and MM; i.e., modules with highest increasing or decreasing expression pattern from mid-gestation to 1 day of extra-uterine life (Additional file 5: Figure S4).
We aimed to obtain psd module variants with increased destabilizing activity at a blue light illumination intensity that does not influence the growth rate of yeast cells (Additional file 1: Figure S1A and [ 35]).
We used the model organism Saccharomyces cerevisiae to generate psd module variants with increased and decreased stabilities in darkness or when exposed to blue light using site-specific and random mutagenesis.
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