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Furthermore, GBM alterations cluster within non-random modules, and the modules are robust across different studies; and a network-based approach can automatically identify and extract biologically relevant GBM modules, which correspond closely to prior known GBM biology.
The network consists of sub-networks (also referred to as modules), which correspond to pathways and processes.
Thus, it appears to be more suitable for finding large functional modules which correspond to general GO terms as opposed to uncovering more specific functional modules.
The Arabidopsis metabolic network is highly modular and separated into 11 interconnected modules, which correspond well to the functional metabolic pathways.
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Baseline data collection including diet and physical activity assessments were performed prior to the start of the educational modules, which corresponded to the fall term for the middle-school students.
The results indicated that the house mouse sperm head is divided into three variational modules (the acrosomal, post-acrosomal and ventral spur module), which correspond to the main regions of the cytoskeletal mesh beneath the plasma membrane, i.e., the perinuclear theca.
At this point, the input network is divided into a set of modules which potentially correspond to real biological complexes.
Many studies have searched for higher level organization and modularity within the network by breaking it up into relatively independent modules, which may correspond to biologically relevant complexes (Han et al., 2004; Kashtan and Alon, 2005; Spirin et al., 2003).
For this, we defined genome-specific module weights, which corresponded to the fraction of the protein families of a module that were annotated for a certain genome or taxonomic bin (completeness scores).
The distinct expression profiles of modules are represented by the module eigengene (Langfelder and Horvath 2007), which correspond to the first principal component of the module expression matrix and which can be regarded as a representative for the gene expression in a module.
The expression pattern of the resulting modules is represented by the module eigengene (ME), which corresponds to the first principal component of a given module.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com