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Before we began to identify the modules, we examined the distribution patterns of gene expression values.
For a finer-grained look at the participants' experiences with the learning modules, we examined the distributions of responses on the individual scale items (descriptively only).
To better understand the relationships between modules, we examined the correlations between eigengenes of each module, and found a very strong negative correlation between the 'blue' and 'turquoise' module eigengenes (correlation = −0.90; Additional file 1: Figure S2).
To better understand the biological functions of identified regulatory modules, we examined them at the systems level by looking for interaction partners for predicted miRNA targets in a large protein-interaction network.
To investigate the prognostic potential of critical nodes and modules, we examined the ability of their corresponding genes to distinguish between poor and good outcomes after MI (specified below).
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The subsequent modules we examine are examples of modules which embody highly non-linear signal processing.
To further explore whether other chemical signals in addition to ROS (H2O2) were also involved in the activation of the putative ROS-bZIP – as1/ocs regulatory module, we examined the effect of exogenous ABA on the expression of representative subset of H2O2-inducible genes by northern blot.
The module we examine is one of negative feedback leading to oscillations (studied in [ 28]).
In this module, we examine the similarities and the differences between some of these models, including a minimal differential equations model of the lac operon (Santillán and Mackey, 2008) and a PDS counterpart based on the same wiring diagram.
We examined one module, module 17, in detail because we are interested in stress responses, as module 17 was found to be enriched with GO terms relating to environment stresses.
As a way to check whether the MTBs we identified represent modules with biological relevance, we examined the expression levels of the miRNAs and mRNAs in human cell lines obtained from RNA-seq experiments performed by the ENCODE Project Consortium [ 23, 24].
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clusters we examined
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dimensions we examined
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