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The function of detected modules was validated by adopting the CYC2008 human-curated complex dataset as benchmark data [ 26].
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Unlike the IHI-GTT where individual modules were validated separately, the CPTT has been validated for use as a single tool for all paediatric populations.
The predicted motifs are ranked and validated with known motifs in other databases, and the predicted motif modules are validated with known TF interactions to facilitate further research.
The predicted motifs and motif modules are validated using known motifs and motif pairs corresponding to the known interacting TF pairs.
In the same computational framework, a large number of predicted gene regulatory modules were validated by gene expression coherence, function enrichment analysis, TF-gene binding potentials, and the literature [ 27- 29, 36- 46].
The module was validated in a pilot-scale membrane bioreactor with the University of Cape Town configuration and submerged flat sheet microfiltration membranes.
The module was validated by comparing depressive symptoms reported by the patients themselves using the M.I.N.I. module with those evaluated by their psychiatrist using DSM-5 criteria during clinical interviewing.
The M.I.N.I. module was validated by comparing depressive symptoms reported by the patients themselves using the M.I.N.I. module with those reported by their psychiatrist assessing the presence of DSM-5 criteria during the clinical interview.
The PR25 module was validated in October 2008 by Aaronson and colleagues [ 6].
This module was validated in an independent material, by replicating the expression changes in allergen-challenged CD4+ cells.
After each test, the module was validated after discussion with users to determine if the function is adapted to their needs.
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