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Storage and transfer modules to contain and distribute the product of these systems will be featured as well.
The flexibility of the fabrication method would allow (i) different modules to contain different types of gel matrix, (ii) single modules to contain controlled mixtures of types of cells, and (iii) modules that contain different types of cells to be mixed.
Because the transcripts that are involved in biological processes may be upregulated or downregulated, a signed network was created that allowed modules to contain positively and negatively correlated genes in different modules.
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At the same time, not all sets of modules need to contain the same amount of modules.
For cases in which our modules overlap with the clusters identified with HC (Schuldiner et al., 2005), our modules tend to contain additional information about pathway cross talk.
Additionally, there is a module designed to contain QoS specifications at the user's level and another one containing basic concepts that are reused by all other modules.
This module appears to contain phage DNA metabolism and replication functions, including predicted aerobic ribonucleoside reductase subunits (phiCbK gp111 and gp112), thymidylate synthase (phiCbK gp116), a RecD-like ExoV helicase (phiCbK gp118), a DNA Pol III-like ribonuclease (phiCbK gp121) and a T7-like DNA polymerase (phiCbK gp123).
Several modules were found to contain little or no connections to the rest of the network (i.e. stand-alone modules), representing genes whose expression is not linked to any other module either directly or via an intermediary gene.
The module was simulated to contain two unrelated sub-modules of 200 and 300 genes, respectively.
Almost all modules were found to contain continuous stretches of disordered residues, which can also play functional roles.
Obvious dockerin modules were expected to contain two Ca + 2-binding repeats, putative helices and linker regions.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com