This scenario is not completely consistent with gag and PR perspectives; for instance, while Micropia/Mdg3 modules preserve the canonical motif, the different Retroviridae genera belonging to class II exhibit different motif polymorphisms.
In this step, we identify the correlation between several candidate drivers and the target genes in every module using the canonical correlation analysis (CCA).
A comparison of the hierarchical partition trees for the unweighted and weighted (Day 12) models shows that the weighted model yields greater functional homogeneity of modules based on the canonical pathway assignments of the constituent reactions.
We have determined a crystal structure of the PH-TH module of Btk bound to IP6 and identified a previously undetected binding site on the PH-TH module, distinct from the canonical PIP3/IP4 site.
We performed pathway enrichment test of the three module gene sets using the canonical KEGG pathways.
EPM2A encodes a protein named laforin that contains a carbohydrate binding module (CBM) followed by the canonical dual specificity phosphatase (DSP) active site motif, HCXXGXXRS/T (Cx5R) [ 9, 11] (Fig. 1A).
With rare exceptions, the modules of class I INTs usually preserve the canonical motif, while the modules of classes II and III exhibit other variants.
Both the canonical pluripotency module and the lineage-antagonism module are incorporated leading into the integrated "seesaw" model.
As a result, 45/61 non canonical proteins contained in the signalling modules are robustly clustered with the canonical proteins (Table 1, Additional file 4).
This top-level module is closely related to the canonical, direct form II, for an IIR digital filter (Grover and Deller, page 254, figure 6-27).
