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The reduced size and focus of the extracted modules tend to facilitate the annotation task.
It turns out that clusters of these genes — sometimes called modules — tend to keep working together over the course of millions of years.
Whereas nucleotides in protein-binding sites in the most proximal regulatory module exhibit reduced variation, those in other modules tend to be more polymorphic than putatively nonfunctional nucleotides.
Comparing the geometric dispositions of the modules of Fig. 1e with the deformed shapes of Fig. 4, it may be seen that the two adjoining modules at joint s tend to change shape as end restrained modules of Fig. 4c, d, whereas all other modules tend to deform as unrestrained rectangular frames such as those depicted in Fig. 4a, b.
Therefore, the modules tend to be biosynthetically isolated from each other.
Their results indicated that the duplicated modules tend to retain similar general functions.
Similar(28)
Contraction also caused some distortion in the shapes of modules: over time, indentations and corners of the modules tended to became rounded (Figure 2A B).
Accordingly, structures composed of several modules tended to show a stronger transgressive pattern when compared to single modules.
Integration between modules tended to be low in the parental strains, and to relate modules from the same (anterior vs. posterior) part of the mandible, and/or neighboring modules.
Furthermore, comprehensive network analyses were performed to further mine the identified driver network properties: mutations in the core modules tended to mutate the hub genes that exhibited central regulatory roles.
More details and numeric values are presented in Additional file 4. The preserved modules tended to be relatively large: Out of 2640 CTX network genes (from merging the CTX data with the blood data), 690 were part of the blue module, 421 were part of the green module and 658 were part of the yellow module.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com