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This observation suggests that BEEM can detect two different types of modules targeted by the other two methods.
The modules targeted by the CC are those related to genomic sequences: core modules (general usage, ontologies and controlled vocabularies) and the sequence feature module.
Moreover, the two sets share only 58 proteins (<15%), indicating that the modules targeted by the two methods are nearly disjoint.
Despite these recent advances, the oncogenic signaling modules targeted by aberrant FAK expression and activity in developing and progressing breast cancers, and their potential role in regulating the activity and composition of associated tumor stroma remain to be fully defined.
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Given the extent to which different STAT members bound to identical genomic sites, the most conserved of these CRMs were of particular interest since they might constitute key cis-regulatory modules targeted primarily by any of the STATs.
To gain insight into the alcohol-responsive gene modules preferentially targeted by alcohol-induced miRNAs, we constructed gene interaction networks based on WGCNA correlation measurements for the red, brown, and turquoise modules.
It can also be shown that many modules contain genes targeted by miRNAs in the same modules (see Section S6 in Supplementary material).
Both questionnaires are considered "core" instruments that can be supplemented by 'specific modules' targeting neoplasms, symptoms or specific treatments [ 3].
Therefore, consistent with the above pooled analyses of target sites of all (potential) modules, target sites of the majority of miRNAs bound by individual (potential) modules were weaker.
Genes in the proliferation module are already targeted by several chemotherapeutic agents, but less harmful drugs are more desirable.
As a typical example of drug-module, ATF3 was targeted by a lot of drugs (upper right of Figure 4).
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