Sentence examples for modules tagged by from inspiring English sources

For modules tagged by at least 1 GWAS locus, we used the Fisher's exact test to assess whether a module was enriched for eSNPs that were also nominally associated (P value ≤ 0.01) with allergic rhinitis.

These 6 modules (the brown, pink, magenta, red, midnight blue, and steel blue coexpression modules) tagged by GWAS loci were therefore considered candidate allergic rhinitis associated modules that could inform on allergic rhinitis biology.

Coexpression modules tagged by GWAS loci were identified as candidate allergic rhinitis associated modules, and then assessed for enrichment of eSNPs that were also nominally associated with allergic rhinitis.

Our approach of using GWAS loci to tag coexpression modules therefore allowed us to gain additional utility from our GWAS results.Among the 6 candidate allergic rhinitis associated modules tagged by GWAS loci, the brown module (representing mitochondrial pathways according to pathway analysis) was tagged by 6 of the 22 GWAS loci.

Finally, we describe the integration of our GWAS and gene expression analyses, where we performed eSNP analysis to assess for the association between genetic variation and gene expression, assessed GWAS loci for eSNPs, identified coexpression modules tagged by GWAS loci, and analyzed coexpression modules for enrichment of allergic-rhinitis associated eSNPs [ 15].

Of note, some of candidate allergic rhinitis associated modules were tagged by GWAS loci that would not have been considered remarkable by traditional criteria for genome-wide significance of individual loci (P value ≤ 5.0 × 10−8).

Motivated by the same rationale that genetic variation that is associated with both the trait and gene expression is more likely to be biologically relevant than variants associated with the trait only, we mapped GWAS loci to CD4+ coexpression modules and examined the modules that were tagged by GWAS loci.

42 RCCX module: The MHC class III risk haplotype, tagged by rs1269852 and rs3130490 showing primary association in the Spanish cohort, spans the copy variable RCCX module containing complement component C4.

In the tag-to-library module, tag sequences are matched to the internal SAGE libraries.

In this study, the yeast temperature-sensitive strains were tagged C-terminally by homologous recombination using 13MYC-KanMX6 moduLongtinetinetet al. 1998).

To accommodate this, there is an optional tag quality module, which assesses the tags by the number of basecalls with PHRED scores of <10.