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The functional enrichment analysis on groups, as well as that on modules, implied the cooperation relationships among modules or groups and confirmed the biological relevance of our hierarchical network.
However, these expansion approaches are module-based methods that focus on identifying modules (or groups) of additional genes to one gene [24] or a group of genes with a fixed topology [25].
We identified several modules or groups of co-expressed orthogroups.
Chado tables are grouped into modules, or groups of tables that store data for related data types (http://gmod.org/wiki/Chado_Modules).org/wiki/Chado_Modules
Yoon and De Micheli introduced the concept of such modules, or groups of miRNAs and target genes that are believed to participate cooperatively in post-transcriptional gene regulation [ 29].
Subsequently, this measure of gene co-expression was used in an automated hierarchical clustering procedure [ 27], resulting in the identification of several distinct modules or groups of genes with similar expression patterns.
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Once modules or functional groups have been identified in any real network, control networks can be grown that mimic the connection pattern or modularity of that network.
No studies yet reported have explored interactions in the regulatory control of mRNA modules by individual or groups of miRNAs.
These marginally housed participants (n = 270) were randomly assigned to either an intervention group (n = 137) that received the Health Living Program modules or a control group (n = 133) that did not receive the modules but were assessed along the same time lines as the intervention group.
Many algorithms identify modules in interaction networks, or groups of densely interconnected genes that can be highly functionally related (King et al. 2004; Newman 2006; Palla et al. 2005; Spirin and Mirny 2003).
Communities or modules are groups of nodes forming tightly connected units that are only weakly linked to each other; they reflect topological relationships between elements of the underlying system and represent functional entities [5], [6].
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