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In addition, we computed modules of human-pathogen PPIs that are conserved amongst the three networks.
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Targeted by many virulence factors of human pathogens.
Animals that live in close contact with humans can be dangerous reservoirs of human pathogens.
Since, simple intersections of host-pathogen PPIs did not yield substantial information on conserved PPI networks, we applied four published algorithms for identifying conserved protein interaction modules (CPIMs) amongst the three human-pathogen networks and homology relationships previously identified: Graemlin [31], Match-and-Split [32], NetworkBLAST [33], and GraphHopper [34].
In the first module, students focus on three genomes of the human pathogen E. coli O157 H7 from separate foodborne outbreaks; a second module centers on student analysis of five genomes of the human pathogen Y. pestis.
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