Here we present cell-type specific gene expression data for 17 distinct cell states and demonstrate that these modules of genes can in fact define cell fate.
Gene module level analysis is based on this module concept, aiming to understand biological network design and systems behavior in disease and development by emphasizing on modules of genes rather than individual genes.
A novel bioinformatics analysis is used to identify modules of genes associated with biological systems (bionetwork).
Furthermore, we found that mRNA expression of entire functional modules of genes is coordinated at this epigenetic level.
With this global human cancer compendium (HCC), they formed modules of genes that regulate cancer in a general way.
The systems biology approach taken with this network analysis of primordial follicle development identified clusters and modules of genes involved in this critical development process.
HCEs thus have frequently been suggested to function as cis-regulatory elements, and several HCEs have been tested as cis-regulatory modules of genes for early development [2].
Second, they contain modules of genes with similarity to genes previously identified in and considered to be characteristic of mobile genetic elements.
Functional annotations, such as GO or KEGG pathways, have been used for the definition of modules of genes, carrying out common functional roles, in functional profiling methods [1], [2].
To move beyond examining single gene effects on this development process, gene network analysis can be employed to identify groups (e.g. modules) of genes whose expression is regulated in a coordinated manner (gene network) [6], [7], [8].
Several GOs (chloroplast - GO 0009507; plastid - GO 0009536; organelle envelope - GO 0031967; organelle membrane - GO 0031090; organelle subcompartment - GO 0031984; and photosynthesis - GO 0015979) identified by both DPC and SVAR suggest that the biclusters represent modules of genes with potential roles in diurnal starch metabolism.
