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We identify nineteen modules of gene expression reflecting multiple waves of transcriptional up- and down-regulation which characterize adipogenic differentiation.
Functional modules of gene coexpression networks were also explored in research of cardiac development, hypertrophy, and failure [ 63].
Then, module maps were constructed using an ensemble of tools provided by the Genomica software [ 41], which searches for higher-order modules of gene sets and samples.
In ferret, modules of gene expression are obvious at multiple locations throughout the developing cortex, systematically mapping the prospective location of folds or fissures, particularly in the OSVZ.
Strong correlations between modules of gene co-expression and health states were identified when the samples were assigned to correct conditions (left).
The domains or modules of gene expression only became distinguishable in early postnatal ferrets, and particularly in the OSVZ (Fig 7).
Similar(49)
Gene co-expression networks can be used to identify modules of genes with similar expression profiles.
Here we present cell-type specific gene expression data for 17 distinct cell states and demonstrate that these modules of genes can in fact define cell fate.
Gene module level analysis is based on this module concept, aiming to understand biological network design and systems behavior in disease and development by emphasizing on modules of genes rather than individual genes.
A novel bioinformatics analysis is used to identify modules of genes associated with biological systems (bionetwork).
Furthermore, we found that mRNA expression of entire functional modules of genes is coordinated at this epigenetic level.
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