Exact(4)
Because the modules may correspond to biological pathways, focusing the analysis on modules amounts to a biologically motivated data reduction scheme.
Because gene modules may correspond to biological pathways, focusing the analysis on modules (and their highly connected intramodular hub genes) amounts to a biologically meaningful data reduction scheme.
Thus, the motifs conserved in the upstream region of the different subfamilies of MazF family TA modules may correspond to regulatory sequences recognized by the distinct N-terminal domain of the antitoxin in each subfamily.
In our sample co-expression network, the GCB cells connect to DLBCL-1 cells while the tonsil and lymph node cells fall in the DLBCL-2 modules, suggesting that the two modules may correspond to the two well-known DLBCL subtypes.
Similar(4)
A functional module may correspond to a protein complex [ 15, 18] or to a signalling pathway [ 22].
Less functionally well defined modules (14%) may correspond to multi-functional modules involved in pathway cross-talk (component annotations are heterogeneous).
Many studies have searched for higher level organization and modularity within the network by breaking it up into relatively independent modules, which may correspond to biologically relevant complexes (Han et al., 2004; Kashtan and Alon, 2005; Spirin et al., 2003).
Moreover, by studying the different relationships to different adjacent nodes, we assume that the prioritized genes can be further divided into sub-modules which may correspond to the subtypes of the disease.
Related(20)
components may correspond
clusters may correspond
nodes may correspond
models may correspond
modules may pack
modules may reduce
modules may overlap
modules may represent
modules may facilitate
modules may allow
modules may enhance
modules may arise
modules may exhibit
modules may result
modules may appear
modules may rearrange
modules may hold
modules may be
modules may provide
modules may have
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