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The workload descriptor consisted of modules labeled by attributes, and a list of values for these attributes was provided.
In total, we identified 20 modules, labeled by colors, with each containing at least 50 genes.
Unsupervised average linkage hierarchical clustering of all genes in this dataset resulted into 13 modules labeled by color and each comprised of mutually exclusive co-expressed genes.
In addition, we utilized high thresholds for module construction for further filtering, resulting in a final gene coexpression network comprising 26,030 genes, including 4,070 lncRNAs, which are distributed among 16 gene modules labeled by colors.
Signed networks were built using biweight midcorrelation as the correlation function, and a soft thresholding power of 12. WGCNA produces a set of modules (labeled by color), each containing a set of unique genes.
Using the same parameters for the clustering and branch detection, we found that two of the 12 modules (labeled by salmon and light-yellow color) in that work are not represented in the consensus modules.
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The modules labelled by colours are depicted in the hierarchical clustering dendrogram provided in Figure 1A.
Here, a total of 46 coexpression modules (labeled numerically, e.g., M29, and by color, e.g., black, see Additional file 2) were obtained for Drosophila development.
The 23 gene co-expression modules are labeled by colors (e.g. the "palegreen" module), with pertinent functional characterizations taken from ref. [ 21].
For example, 45% (p = 2.8 × 10-53) of genes overlapped between the yellow cortex module (labeled yellow/CTX) and yellow caudate nucleus module (labeled yellow/CN).
The HDC consists of calculating the Hamming distance between the received sequence and the coded sequence at each edge of a section t of the trellis module M. As each edge is labeled by l t bits, the same amount of bit comparison operations is required.
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