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By using genetic engineering to mix the modules in specific proportions, proteins with defined strength and elasticity can be designed, which have many potential medical and engineering uses.
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This can be done by placing the leading (underlined) and trailing (overlined) 1's of each row of the "matrix module" in specific positions, leaving the other positions free to assume any binary value.
It is therefore possible that the MBD1 CxxC-3 domain may act as a relevant targeting module in specific instances where DNA methylation levels are drastically reduced, for example, in pre-implantation embryos [ 96].
However, little is known about the modules that exist in miRNA-gene regulation systems, and even less is known about these modules' role in specific biological processes and key regulation assemblies.
The regulatory effect of SMAD complex likely depends on transcriptional modules, in which the SMAD binding elements and partner transcription factor binding sites (SMAD modules) are present in specific context.
We found that different modules were enriched in specific ontologies (Table 7), reflecting the modularity of gene expression.
The restriction endonuclease PvuII has been introduced as a sequence-specific cleavage module in highly-specific nucleases for gene targeting.
Module co-expression was evaluated by calculating the average pair-wise Pearson correlation between all genes for a module in a specific dataset.
We also selected a structure where plug-in modules handling specific tasks could be added to the system as needed.
Taken together these data provide valuable guidance to the design of experiments that seek to identify regulatory modules in genes with specific patterns of expression.
In the regulatory networks of the nine modules, DNA methylation and genomic elements are present only in specific modules, implying that they are not necessarily common regulatory initiators.
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