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The identification of modules in complex networks has attracted much attention of the scientific community in the last years, and social networks constitute a prominent example.
A thorough understanding and mathematical description of these modules in complex organisms would further pave the way to exploit such circuits within systems biology and also for applications in gene or cell therapy [8].
Modules in complex systems tend to be highly internally connected whilst sharing only a few connections with the outside world.
The identification of modules in complex networks has attracted much attention of the scientific community in the last years.
Methodologies that aim to overcome resolution limits can provide deeper insights into finer structures of modules in complex networks and a more accurate depiction of community structure on the basis of the modularity measure.
The higher eukaryotic cell has an extensive repertoire of DNA, RNA and peptide motifs that function as dynamic binding modules in complex formation, recruiters of basal regulatory pathways, or receivers of cell state information through association with or modification by their interaction partner [ 6– 8].
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Regarding the ease of use of possible data management solutions, the Open Source molecular editor and visualizer Avogadro http://avogadro.openmolecules.net can certainly be used as a useful module in complex projects, and in fact the design of Quixote is being carried out in collaboration with the developers of Avogadro, with the intention of efficiently interfacing it in future versions.
Large interconnected modules result in complex system of higher order and often of interval structure, making the overall study and analysis, time consuming and complicated.
Individual gene expression value change is able to indicate the possible relation between this gene and disease but cannot identify the interaction between different genes and the plurality of pathogenic genes as a functional module in the complex disease [ 33, 34].
Various functional modules in the AddAB complex appear at different points along each of the two channels.
While the control design focus of PCSSP applications tends to require only a moderate level of accuracy and complexity in modules, more complex codes can be embedded or connected to access higher accuracy if needed.
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