Each of these modules has a specific task-orientation, and does its work independently of much of what is going on in the rest of the system.
In this way, a larger overall number of patterns can be stored by the ANN ensemble, where each of its modules has a moderate pattern load, being able to retrieve its corresponding assigned subset with the desired quality.
Each of these modules has a distinct sequence (Fig. 2A, supplementary material Fig. S2).
Inhibition activity at multiple sites (v3, v16, v23, and v25) in the upstream modules has a limited affect on ERK activation compared to single target inhibition.
The drug-disease link is established based on the P-value of the hyper-geometric test (5) to determine whether the gene module (from the selected prognosis gene modules) has a significant overlap with the sensitivity module of the drug.
We previously demonstrated that the inference of these so-called coexpressed PPI modules has a high reproducibility across multiple expression datasets in breast cancer (van den Akker et al., 2011), and here we extend this algorithm to combine multiple gene expression datasets on aging.
