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This suggests that even the cortex, midbrain and brainstem, as well as the thalamus, can consist of complex structural modules formed by the projection-based parcellation of L5 motor cortical neurons.
We designed a strategy for microarray analysis that is based on the identification of transcriptional modules formed by genes coordinately expressed in multiple disease data sets.
The sectionalized heat transfer surface of the steam generator is made up of modules formed by series-connected single cylindrical coils wound around a displacer.
Briefly, this is a systems-scale strategy for microarray analysis that has identified transcriptional modules formed by genes coordinately expressed across multiple disease data sets thus allowing functional interpretation of the microarray data into biologically useful information.
Another example is modules formed by genes and their regulators, such as TFs or microRNAs.
An important aspect of MLDMs is that they can be linked to modules formed by other clinical data.
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We computationally predicted a promoter module formed by conserved consensus motifs for the transcription factors E2F and NF-kappaB present on 1901 human known promoters.
It has been shown that Swr1, Yaf9, the bromodomain-containing Bdf1 protein and the module formed by Swc2, Swc6, Arp6 and Swc3 are required for Htz1 incorporation into chromatin [9], [10], [16], [17], [23], but except for Swr1 the specific function of the remaining subunits and therefore the mechanism of replacement are still obscure.
Consider, for example, one disease module formed by mRNAs and another from single nucleotide polymorphisms (SNPs).
For instance, with respect to the liver module formed by 48 AWM nodes and 359 edges (based on co-association analysis) we observed that 28.9% (104/359) of the predicted gene-gene interactions were validated by the co-expression results.
It suggested that the module formed by the common targets position in the network's core; it might be not accidental that most viruses utilized these nodes as targets.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com