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In additional to the canonical SMAD mediated TGF β signaling module, we identified two interesting modules centered on SOX4 and TGFBI (GENE ID 7045).
Our analysis also suggests that network modules centered on functional hubs are likely to be relevant to the disease phenotype, in this case psoriasis.
The network modules, centered on cistrons containing genes encoding regulatory proteins, contain potential interactions between genes encoding regulatory proteins and their targets.
Such a connectivity pattern indicates that the subgraphs (modules) centered on these hub nodes are important for accomplishing specific biological functions.
A supplementary package, pathprintTF, is also provided, containing a similar framework and database to pathprint but built upon protein interaction modules centered on transcription factors rather than pathways to enable cross-platform comparison of transcriptional control elements.
The common pathways are translation factors and class B secretin-like G protein-coupled receptors (GPCRs) from Wikipathways, and static modules centered on 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-2 (PLCG2) and RAS-related nuclear protein (RAN).
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For example, functional analysis was used to identify an ABA module centered on two sucrose nonfermenting (SNF -like kinaSNF -like
Our network analysis identified a subnetwork module centered on PfGCN5 (PF3D7_0823300), a bona fide histone acetyltransferase.
It had three modules, each module centered on the focus paper(s), with five meetings in each module.
In the 5-edge group of patterns, we have identified a functional module centered on the well-known oncogene MYC, and Myc binding proteins, Max, Mycbp2 (PAM), and SP1, that are differentially regulated in nine cancers.
The layer deposition process adjustments and further module technology improvements that led to a significant increase in the absolute stabilized module conversion efficiency of large area (1.43 m2) tandem MICROMORPH™ modules centered first on obtaining high quality amorphous TF-Si deposited materials for the top cell.
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