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Next we identified the enriched GO functional categories of these column modules by mapping them to GO items (hypergeometric test).
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After KEGG and GO annotations, we have validated our modules (Table 7) by mapping them to known complexes in MIPS [ 49].
Disease modules were then constructed by mapping the cliques that had a significantly higher weight than expected by the null distribution (P < 0.01).
This score was normalized in a similar way as previously described, where the initial known modules were defined using the minimal co-regulation module definition and subsequently randomly permuted by mapping the genes within the modules to a random permutation.
Our annotation emphasizes the inherent modularity in the available datasets, as shown by mapping the extracted modules to known complexes.
E Perform IGEA by mapping gene-based GWAS findings to the identified GS BC modules.
Metabolic mapping of the metatranscriptome profiles was performed quantitatively by mapping the KEGG annotation of the identified protein sequences onto metabolic pathway maps using the iPath v2 module (http://pathways.embl.de/iPath2.cgi#).de/iPath2.cgi
The author obtained the numbers of methylated genes in these two modules by first mapping methylated genes into genes in these two modules and then counting the numbers of mapped methylated genes in Module One and Module Two, respectively.
Additionally this method can reveal the biological meaning of the detected SNP combination by mapping functional modules and mapping the T2D-related information at multiple levels including disease genes.
Likewise, Brca1 and its homolog Mcph1, the Msh family of proteins, and a Rad/Dmc module were detected as stemness modules by S-MAP (Figure S5c).
METSP is implemented by using JAVA language and consists of data downloadable module, preprocessing module, ME classifier module, compound name mapping module, and assisting manual validation module.
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