Sentence examples for modules bound by from inspiring English sources

The basic building blocks for such promoters are regions of cis-regulatory DNA, which in eukaryotes often comprise clusters of cis-regulatory elements (CREs) (called composite motifs, or modules) bound by a combination of transcription factors (TFs).

Interestingly, the distance of target sites bound by miRNAs in the same modules was shorter when miRNA modules bound unconventional instead of canonical sites.

The activity of cis-regulatory modules might also change when different subsets of cis-elements of the cis-regulatory modules are bound by transcription factors.

Cis-regulatory modules are bound by transcription factors to regulate gene expression.

In addition, we analyzed how genes of a given module are bound by chromatin regulators or pluripotency TFs by incorporating independent promoter binding information.

Modules are related to TFs by the hypergeometric test, which assesses the probability that the observed frequency that the genes in a module are bound by a TF would occur by chance.

A similar observation was made for the 306 potential modules, for which target sites of 51 of the 68 miRNAs bound by modules were weaker and target sites of only 7 of the 68 miRNAs bound by modules were stronger (FDR = 0.05).

We observed that the target sites of these predicted modules were in general weaker compared with those not bound by miRNA modules.

Table 1 shows module enrichment of genes bound by TFs in the Oct4 group, the cMyc group, and Suz12 for modules in the unsigned and signed networks.

Thus, Module 9 is the union of Modules 6, 4 and 82. Figure 5 displays genes from Module 9 that are bound by the TFs, which are significantly related to the set of sulfur regulated genes.

We observed that target sites of these predicted modules were in general weaker compared with target sites not bound by miRNA modules.