Our network-based strategy identified two survival-associated modules associated with ovarian cancer progression.
Finally, we found 414 miRNAs that may regulate one or several modules associated with clinical improvement.
Our analysis of several cell shape changes leads us to propose four regulatory modules associated with ratchet-like deformations that are tuned to generate diverse cell behaviors, coordinating cell shape change across a tissue.
S-MAP identified many stemness modules associated with DNA repair, including the Terf, p53, and Rad families (Figure 5B; Figure S5c).
Based on existing annotation of modules associated with vesicle transport, any relationship (edge) between two members of the same module is considered "true", all other relationships "false".
We developed a Stemness Index (SI) to contrast the degree to which a study upregulates modules associated with stemness compared to those associated with differentiated cells.
To uncover epigenomic and genomic patterns, CpG loci are clustered into nine modules associated with distinct chromatin and genomic signatures based on terms of biological function.
Together, our results suggest that PCN regulates development of secondary vascular tissues, potentially through regulation of transcriptional modules associated with cell differentiation and/or hormone-mediated processes.
For example, Xue et al. have characterized protein protein interaction network modules associated with aging in humans and flies and performed limited biological validation of their network in Caenorhabditis elegans [9].
S-MAP detected several chromatin-related modules associated with stemness including those involved in imprinting, chromatin-dependent silencing (PRC1 and PRC2 complexes), heterochromatin and the nuclear lamina, which may indicate widespread suppression of lineage-associated genes.
Our goal was to identify modules associated with line differences.
