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We tried using a novel method for evaluating module preservation [ 34] to check whether modules are preserved in terms of density and connectivity between the species regardless of the parameters used to obtain the modules.
A composite preservation statistic, Zsummary, can be used to evaluate whether modules are preserved.
For example, we evaluate which CTX brain modules are preserved in the CN and CB data.
In addition, WGCNA offers functionality to assess whether gene modules are preserved in other networks [ 19].
Therefore, the number of replaced hyperedges consecutively decreases as the structure learning proceeds, while high-discriminative modules are preserved.
Modules are preserved when genes with the same color continue to cluster together based on their topological measure in the separate networks.
Similar(52)
To discriminate changes in modules comparing SZP and CTS, we performed a module Preservation analysis that identified which modules were preserved in both datasets.
55 of the 294 modules were preserved with Zsummary (module) >5.
Although few modules were preserved, they tended to be relatively large.
When we compared our findings with spinal cord data from the same individuals, only two of the ten modules were preserved in spinal cord (i.e. Magenta and Turquoise).
In this work we present methods a) for finding consensus modules across multiple networks, b) for describing the relationship between consensus modules (eigengene networks), and c) for assessing whether the relationship between consensus modules is preserved across different networks (differential eigengene network analysis).
More suggestions(15)
clusters are preserved
dimensions are preserved
simulations are preserved
nodes are preserved
components are preserved
modules are described
modules are stored
modules are grouped
modules are calculated
modules are supplied
modules are connected
modules are called
modules are considered
modules are assembled
modules are done
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