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In this case, gene ontology information suggests that the two modules are indeed distinct.
And the result shows that the discovered modules are indeed functionally coherent.
From the analysis of the genes belonging to our identified modules, we can see that these modules are indeed related to the development of OLP.
The evidence supports from literature demonstrate that the miRNA regulators of our identified modules are indeed related to the development of oral cancer.
The overlap between our identified module genes and those known oral cancer genes indicates that our identified modules are indeed related to the development of oral cancer.
This is why functional enrichment analyses, module preservation studies across array platforms, and other forms of validation are required to verify that co-expression modules are indeed biologically meaningful.
Similar(51)
The interface between the Head and Middle modules is indeed important, facilitating a reorganization of Mediator's structure and inducing a conformation compatible with RNAPII binding.
There are no overlapping pathways between both modules, suggesting that the MYC module and the core module are indeed involved in very different pathway patterns in regulating pluripotency and self-renewal of ES cells.
The proximal validation of this approach relies on demonstrating that the processual case conceptualization accurately identifies the psychological processes that maintain the problem and that each module is indeed effective in altering the psychological process it targets.
Gene Ontology (GO) analysis demonstrated that major GO terms associated with the blue module were indeed related to neurons including "synapse maturation", "neuronal projection extension", "dendrite morphogenesis", "synaptic vesicle endocytosis", and "telencephalon development" (Fig. 2G).
HIMIA successfully identified three genes for trehalose synthease subunits: TSL1 (in module 25), TSP1, and NTH1 (both in module 26) are indeed regulated by Msn2 or Msn4.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com