Sentence examples for modules are enriched from inspiring English sources
Fifty-four modules are enriched in targets of one or more TFs, and 39 modules show enrichment of both GO Biological Process categories and TF binding sites.
Conserved modules are enriched in genes associated with ASD, supporting the utility of phNPCs for studying neuropsychiatric disease.
For the F-aucodds score we calculated an aucodds score as described earlier in both the dimension of the gene sets (denoting how well all functional sets are covered by the observed modules) and the dimension of the observed modules (denoting how well the modules are enriched in at least one function gene set), and combined both scores by calculating its harmonic mean.
Both modules are enriched with the function of binding but tend to bind with different molecules.
It has been demonstrate that these types of modules are enriched for known biological pathways for genes that associate with disease traits and for genes that are linked to common genetic loci [6], [35].
Thus, dioxin-enabled modules are enriched in links that appeared only in the treated condition (e.g., Fig. 2E), and dioxin-sensitive modules were enriched in links observed only in the normal condition (i.e., were vulnerable to disruption by dioxin).
These modules were enriched with the genes relevant to cell cycle and immune response.
On the other hand, a substantial number of all known modules were enriched in at least one functional term, ranging from 30% to 60% on GO terms and 30%to50%0% on KEGG pathways (Supplementary Fig. 20b).
Other coordinately expressed modules were enriched for lymphoid and/or myeloid signature transcripts and genes induced by IL-17 in keratinocytes.
A few convergent gene and enhancer modules were enriched in autism-associated genes and genomic variants in autistic children.
A comparison to the results of Wong et al. (2008) [6] demonstrated that the homolog modules were enriched for modules of higher recurrence than the modules reported in the Stemness Module Map (Figure S3).
