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Second, co-expression modules are conserved across species and are organized into coherent functions [ 32, 33].
We then demonstrate that interactions that are part of functional modules are conserved at much higher rates than previous reports in the literature, while interactions that connect between distinct functional modules are conserved at lower rates.
It may be worth noting that only G modules are conserved in many BAPs (Additional file 5).
Our results indicate that while, in general, interactions at the node (protein) level are conserved at low rates, interactions within modules are conserved to a much greater degree.
Some of these modules are conserved in sequence, but their function is still unknown; some may represent a yet undiscovered enzyme.
Finally, we show that certain critical modules are conserved from one network to another, and that in many cases it is possible to extend the relationship between connectivity and essentiality or between connectivity and conservation within given modules.
Similar(52)
While some important expression modules were conserved, many others were not.
The evolutionary analysis showed that the coding sequences of most of the module genes in the coexpression network modules were conserved among pig breeds under artificial selection.
These results indicate that while gene-gene interactions are not well conserved, the overall network, through the intermediate level of modules, is conserved to a much higher degree.
No integral RGP was conserved in all four genomes and, as previously described, only subregions of RGP, named modules, were conserved.
To assess the degree to which A. callidryas modules were conserved across the other three species, module preservation statistics were computed using the modulePreservation function (500 permutations) (Langfelder et al. 2011).
More suggestions(15)
models are conserved
elements are conserved
clusters are conserved
modules are described
modules are stored
modules are grouped
modules are calculated
modules are supplied
modules are connected
modules are called
modules are considered
modules are assembled
modules are done
modules are depicted
modules are labeled
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