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Cis-regulatory modules are bound by transcription factors to regulate gene expression.
The activity of cis-regulatory modules might also change when different subsets of cis-elements of the cis-regulatory modules are bound by transcription factors.
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In addition, we analyzed how genes of a given module are bound by chromatin regulators or pluripotency TFs by incorporating independent promoter binding information.
Modules are related to TFs by the hypergeometric test, which assesses the probability that the observed frequency that the genes in a module are bound by a TF would occur by chance.
Thus, Module 9 is the union of Modules 6, 4 and 82. Figure 5 displays genes from Module 9 that are bound by the TFs, which are significantly related to the set of sulfur regulated genes.
The distribution of genes and regulatory modules reveal that many genes are bound by multiple TFs.
They are bound to.
No doubt, the customer service reps are bound to see a thing or two during the initial stages, but Shokrian says that anyone who behaves inappropriately will be immediately blocked from using the module.
The two are bound together.
For example, in the 1J84 entry from PDB, the carbohydrate-binding module (CBM) is bound to cellotretraose, a 1,4-β-D-glucan composed of four ß-D-glucose residues linked by ß-1,4 osidic linkages.
Figure 7 also shows that genes positively connected to the black module tend to be bound by more ES cell related TFs compared to the negatively connected genes, supporting the idea that these TFs bind and activate pluripotency and self-renewal genes [ 13].
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