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To examine the impact of specific pathway modules on differential ERK activities, we divided the entire EGFR pathway into three modules and only perturbed parameters that were involved in a particular subsystem.
It must also be emphasized that 90% of our cross-links are between protein subunits in the same module, whereas only 6% are between proteins in different modules, and only 4% are between Mediator subunits and Pol II.
Interestingly, the CNneg1 module of the caudate nucleus network, which represented the "neuron/synaptic" module had only 7 hub genes overlap within several cerebellum modules and only 3 hub genes overlap in the frontal cortex BA4 region network, indicating its tissue specific character (data not shown).
Most of the day 0 modules (21 of 30 modules) were seen to be strongly preserved at day 2 including the pink and magenta modules, eight were weakly to moderately preserved including the grey60 and darkorange modules and only one was not preserved.
We verified (see Additional file 1) that modules ranking at the top 5 positions confirmed after calibration their pre-assigned confidence levels (overall, 18 rank places are taken by High Confidence modules, 9 by Low Confidence modules and only 3 by Medium Confidence modules, but the latter were marginally present and even missing in MCODE).
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The author counted the numbers of samples that have gene mutations in both modules, only in Module One, and only in Module Two, respectively.
This was done to avoid misuse of the module and only restrict the authorized number to know the status of the fuel level.
First, we do not know how many residents completed the online module, and only onsite residents attended Modules 2 to 4. We hypothesized that this learner-based curriculum would spur discussions with residents not in attendance, thus possibly favoring error reduction even if residents were directly exposed to only some of the information.
To ensure the specificity of inter-module interaction, we control the gene module size and only gene modules containing between 100 and 200 genes were selected.
Now we are in the state to prove the following: A QTAG-module M which is a strong ω-elongation of a totally projective module by a (ω+1 -projective module, is a Σ-module if and only if M is a totally projective module.
A module M is summable and a strong ω-elongation of a totally projective module by a (ω+1 -projective module if and only if M is a totally projective module of length ≤ω+1 -projective
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