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From the left panel in Figure 6 we can conclude that, although the BCC modules have a lower median rank compared to the HCC modules, S456 modules, and Genes, there is not enough statistical evidence (at the 0.05 level) to support the claim that the BCC modules outperform the HCC modules, S456 modules, or the Genes.
Thus, the meta-modules of this application correspond to biologically meaningful super-sets of modules and genes.
Then, one can use a number of inferential techniques to link phenotypic attributes to their corresponding signaling modules and genes.
After selection of modules and genes retained in those modules, we investigated those modules using several different module characteristics.
The number of coexpression modules and genes gradually increased with the progress of zygote development, which implied the formation of embryo complexity and modularity.
The outbreak plasmids contained resistance genes, plasmid addiction modules, and genes encoding systems protecting host bacteria against bacteriophages or plasmids, which may have contributed to the strain's dominance and stable persistence.
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For that reason we have created dedicated importers to facilitate the import of the most commonly used modules and gene-sets such as Gene Ontology terms.
In addition, the characteristics of the parent proteins were examined with respect to their modular architecture with a focus on carbohydrate-active modules and gene expression levels.
The modelling of regulatory networks, coexpression modules and gene 'noise' remains currently under-explored in single-cell genomics.
RCCX is prone to nonallelic homologous recombination (NAHR) such as unequal crossover, generating duplications and deletions of RCCX modules, and gene conversion.
A similar systems biology approach has been used previously to identify coordinately and interconnected expressed gene modules and gene networks that regulate the primordial to primary follicle transition which is the subsequent stage of ovarian follicle development [ 31].
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