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Interestingly, all the genes within this erythroid-specific module were significantly downregulated upon Wnt inhibition, albeit they still expressed higher than the levels found within WT erythroblasts (Fig. 5f h).
Moreover, flow-through and elution peaks obtained with the novel membrane module were significantly sharper and more symmetrical, with lower peak width.
The hub genes in the LT-dark red module were significantly enriched for genes involved in cellular response (RRAGD, EPHX1, TPD52 and PSMA2).
The hub genes in the Lde-black module were significantly enriched for genes involved in the regulation of alternative splicing (ZRANB2, RNPS1, and SRSF6).
One-sided Fisher's Exact Test was used to test whether the genes in a module were significantly enriched in any KEGG non-metabolic pathways.
Some genes from the phage lytic module were significantly more highly expressed in subjects with periodontal disease, suggesting that periodontitis may favor the expression of some lytic phages.
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We show that the effective optical width of the front metal fingers in the module is significantly reduced by 54%.
This module is significantly associated with disease progression on both the datasets from Vijver et al. [4] (p<0.0001) and Wang et al. [3] (p = 0.0127).
Interestingly, the Myellow module was significantly enriched for cell-cycle regulation (Bonferroni-adjusted p-value = 1.2E−31).
Similarly, the Retina Global Up module is significantly enriched in inflammatory genes (P = 1.3 × 10-4).
The MME FEM module was significantly enriched for genes in endothelin pathways.
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