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We observed that the majority of miRNAs in this module were dysregulated in neurological diseases.
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Levels of phosphorylated VASP were diminished, and PTHrP levels were dysregulated.
Additionally, genes related to synaptic plasticity, as well as myelin basic protein (MBP), were dysregulated.
Specific miRNA families at targeted chromosomal loci were dysregulated.
27/68 miRNAs were dysregulated greater than 2 fold.
Two modules that are dysregulated in tumor samples are enriched in cell adhesion (35) and growth factor-related genes (93).
This study describes the identification of a group of 445 genes, which are associated with at least two well-defined biological modules that are dysregulated acutely in response to TLR4 activation and for a prolonged period in response to injury.
This module is shown to be dysregulated in glioblastoma samples, and in "cross-talk" with EGFR and p53 signaling pathways [ 53].
We compared the metal-modulated gene sets to genes known to be dysregulated under certain physiological and environmental conditions (e.g. cancer modules) [ 17].
For example, two interferon response genes, IFITM2 and IFITM3, that are dysregulated in ASD brains [ 33] and the light green module in TS, as well as RPS6KA2 and AKT1 in the black module, highlight potential convergent molecular links between TS and ASD that warrant future experimental investigation.
To take another example, three of the seven miRNAs in module 16 (miR-96, miR-182*, miR-183) are clustered on chromosome 7q32.2 and are reported to be dysregulated in various cancers.
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