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The mean scale scores were found to discriminate between trial patients before and after starting chemotherapy, and the OV28 module was indicated as a promising tool for the assessment of QoL of women with ovarian cancer.
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The set of phenotypes associated with the genes in each module are indicated in the middle column.
Nevertheless, we recommend working through the modules in the order presented below, as long as no specific module is indicated (e.g., strong craving).
Biological function of the individual modules was indicated by testing for over-represented Gene Ontology categories as described below.
Different modules are indicated by means of different colors (see text).
Using the rules described in the text, an in silico proteome is obtained (a) displaying all features observed in real protein interaction networks, including modularity (modules are indicated by different colors).
Modules are indicated by the color bands below the dendrogram.
TR annotation (locus name, gene name and description), first time point of differential expression, predicted influenced modules and the enriched functions of those modules are indicated.
The participation of an entity in various modules is indicated in the protein's annotation callout by a link which leads to a separate module map(s).
Data processing was done by in-house python (version 2.6) scripts, except where the use of other software modules is indicated.
Therefore, the boundaries of the modules are indicated by molecules or nodes of high connectivity, where bottlenecks in the signaling network may occur.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com