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To associate the co-expression network modules to changes in these disease parameters, the eigengene (first principal component, see [ 22]) of each module was correlated to the measured physiological parameters by Pearson correlation.
The second module was correlated with triglyceride variation on the high-sugar diet (P = 0.0359).
The yellow module was correlated with AD (cor: 0.69, p: 9.3e-42) and included genes related to cell death, apoptosis, and development (Additional file 1: Table S1).
The list of differentially expressed genes in each module was correlated to signaling pathway and cellular process databases to determine if specific physiological processes were associated with particular modules (see Methods).
Remarkably, several SAT modules were correlated to plasma HDL cholesterol levels and one VAT module was correlated to plasma glucose levels, although these SAT modules contained primarily the same genes as the VAT module.
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The major and minor energy loss characteristics of the module were correlated with the physical module parameters and the flow conditions in the pipe.
Each motility module is correlated with a unique combination of cell edge dynamics, localization of the cytoskeletal protein VASP, traction-force generation, and response to inhibition of actin polymerization by cytochalasin D. We propose that regulatory pathways give rise to particular combinations of local motility modules, resulting in a global functional phase of the cell.
The eigengenes of the resulting modules (the first principal component of the expression matrix corresponding to the genes included in the module) were correlated with health states (H, AL, or D).
To our surprise, none of the modules was correlated with tumor stage (FDR > 0.46).
Only one of these modules was correlated with insulin sensitivity (Additional file 1: Table S12).> -wrap-foot> modulardifferentialential connectivity; FDR, false discovery rate; SI, insulin sensitivity derived from MINMOD analysis of FSIVGT; AA.DE, genes differentially expressed in AA compared to CA subjects.
This combined network analysis and modules were correlated with the mate preference behavior, but no significant correlations were found using this combined analysis (Additional file 7: Table S4).
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