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Figure 1(c) illustrates a condition-specific module that appears in five leukemia co-expression networks across different conditions.
Our working hypothesis described in this model is that gene expression during the initial 24 hours at 10°C can be defined (at least partially) in terms of a regulatory cluster (transcription factor-target gene module) that appears to be independent of the CBF/DREB and ABA-mediated regulons.
So far, only two metazoan motor proteins with similar integrative potential have been described: CHO1, an alternatively spliced variant of the MKLP1 kinesin (Kuriyama et al, 2002) containing an actin-binding module that appears, however, dispensable for the kinesin's function in cytokinesis (Matuliene and Kuriyama, 2004).
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Clusters of gene modules that appeared the most relevant to differentiate [PIP+] and [PIP−] subgroups were identified using t-statistics with a permutation-based adjustment of the gene expression matrix (n = 10,000 and α = 0.05).
Of course, there may be functionally important modules that appear infrequently and would be missed by our analysis.
We were able to identify transcriptional modules that appear to be robust and for which broad biological function could be assigned to.
Despite the large number, we can extract structural features from the models, such as links that are always (or never) present or modules that appear in a mutual exclusive fashion.
The TPRs serve as protein protein interaction modules that appear to target OGT to accessory proteins and potential substrates, such as the related OIP106 (OGT-interacting protein 106) and PP1 (protein phosphatase 1) [ 19].
The patent, which was originally filed back in late 2005 but was unearthed today, depicts a central "module-controller" that appears to lie at the heart of the media center.
All these data indicate the existence of an ancient four-module Mediator complex that appeared early in eukaryotic evolution (Bourbon 2008).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com