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Previous studies have revealed that nodes in a network module tend to work together to achieve a specific function [21], [22].
Genes within one module tend to participate in similar biological processes.
We found that genes in the same module tend to be involved in a set of focused signaling pathways.
This hypothesis is further supported by the observation that proteins belonging to a certain module tend to be coexpressed [ 29] and coregulated [ 30].
However, it was cautiously noted that although the genes associated with the module tend to have higher expression, the histone modifications do not uniquely determine gene expression.
These observations agree with previous results providing evidence that yeast proteins belonging to the same functional module tend to have more similar evolutionary rates than those belonging to different modules [ 70].
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In addition, if the AUC is greater than 0.5, it indicates that the module tends to be upregulated in SCLC compared to that in NSCLC or vice versa.
We also observed that most diseases in the same co-regulated module tended to belong to the same disease category, indicating that these diseases might share similar miRNA regulatory mechanisms.
It turns out that clusters of these genes — sometimes called modules — tend to keep working together over the course of millions of years.
The reduced size and focus of the extracted modules tend to facilitate the annotation task.
Generally flat PV-modules tend to be blind earlier, which is why we expect the effects of PV-coverage to be more relevant in areas of low latitude zones as described for dust deposition (Beattie et al., 2012).
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com