Students in the cell biology module showed similar improvement, though not as strongly as in the genetics course.
In general, volatile compounds included in the same module showed similar LOD profiles in defined regions of chromosomes, suggesting the presence of loci that increase the production of whole volatile modules.
Since some of the gene modules showed similar expression patterns with subtle differences, gene modules were combined according to the time or genotype or time and genotype effects, and subjected to hierarchical clustering to have a broader overview of the patterns of transcript abundance.
Twelve of the top 15 hub genes in this module show similar striatal enrichment in human brain (43), including, as expected, genes associated with dopaminergic signaling (ARPP-21 and PPP1R1B) and GABAergic (GAD2/ Gand5 and SLC31A1/ VGAT) neurons.
We found that components of the same module generally showed similar responses to a given treatment, although some differences were observed.
The IVIS and our OI module show a similar attenuation behavior; at 7 mm the signal has already dropped by ~30%, and at 14 mm it is close to the fluorescence background level of the phantom.
All CCN proteins except CCN5 – which lacks the CT module – show a similar multimodular organization.
The most highly-connected and most closely correlated gene to the Eigen gene for each module showed very similar expression patterns for all modules and we have therefore only plotted the most highly connected genes.
This effect was tested for two modules and both show similar trends, serving as a validation for the general concept regardless of the module specifications.
Five modules were identified showing similar expression patterns between IA and RR samples but differences in expression from WT samples.
