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Contrary to the conventional point of view, we propose to deem the multi-modeling as building a modular architecture, inspired from Artificial Neural Networks operation mode, where each neuron (module), represented by one of the local models, realizes some higher level transfer function.
A pre-defined group of genes was tested to see whether they may regulate the expression levels of the genes in a particular module, represented by the global probabilistic score (Prob. Score).
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Each of the five modules (represented by single white ovals) spans on 1 2 weeks.
Cluster dendrogram of the gene co-expression modules represented by different colors.
To further find more complex associations between gene modules represented by their eigengenes and cell wall properties, we used canonical correlation analysis (CCA).
This raises questions regarding the architecture of trans-AT PKS shift-modules, represented by module 14 of PksX (generally composed of a condensation-incompetent KS, an EI, and an ACP domain).
Instead, we use the following dissimilarity D i s s i m I J (A E i g e n ) = 1 − cor (E I, E J ) 2. Using this dissimilarity as input to average linkage hierarchical clustering leads to a cluster tree of modules (represented by eigengenes).
The expression profile of a given module was represented by its first principal component (module eigengene) which can explain the most variation of the module expression levels.
The expression pattern of the resulting modules is represented by the module eigengene (ME), which corresponds to the first principal component of a given module.
The distinct expression profiles of modules are represented by the module eigengene (Langfelder and Horvath 2007), which correspond to the first principal component of the module expression matrix and which can be regarded as a representative for the gene expression in a module.
Modularity results for the most representative subject are shown in brain space, where each module is represented by a different color (Figure 8).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com