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Gentrepid uses two modules: Common Pathway Scanning (CPS) and Common Module Profiling (CMP) to make candidate gene predictions.
To facilitate understanding of the biological linkage between diseases and mutations, a Bayesian network based scoring system was built in our platform, which integrates both topological and biological features, including disease neighbor density by common module profiling score (CMP) [ 17], disease gene function similarity by Shared Smallest Biological Processes score (SSBP) [ 18].
The Gentrepid tool and its knowledge base utilizes two independent methods: Common Pathway Scanning (CPS), a systems biology approach; and Common Module Profiling (CMP), a domain-based homology recognition approach, to prioritize candidate genes for human inherited disorders (see Methods for details).
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On the other hand, the simplification represents the strength of the method bundle, as it ensures a "generic" quality as well as repeatability of the workflow of standard planning situations for many regions, which is also an important part of the research module profile.
The CNV module profiles genome-wide CNVs.
Fifth, MET module profiles gene-centric cytosine methylation level (Additional file 3), a gene whose methylation levels of promoter, gene body, intron and exon are listed in a summary table.
Here we performed the computational genome-wide screening for potential CRMs using different prediction tools and constructed the pioneer database, cisMEP (cis-regulatory module epigenetic profile database), to integrate these computationally identified CRMs with genomic epigenetic profile data.
To define a representative module expression profile (referred to as the module eigengene), we summarized the (standardized) gene expression profiles of the module eigengene (= first principal component).
To define a representative module expression profile (referred to as the module eigengene), we summarized the (standardized) gene expression profiles of the module by their first principal component.
Finally, in the mitigation module risk profiles for the calculated consequences can be calculated and compared to alternative solutions by assignment of a cost function to the consequences.
In the newly-added horizontal control module, intensive profile points in the evenly distributed radial directions of the horizontal section were used to estimate the horizontal error distribution along the horizontal sectional profile during the forming process.
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