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The total module overlap (TMO) was computed as the sum of all of the module overlap scores for both the positive and negative gene lists; i.e. TMO Q+,Q−) = 1/2 * (SO(Q+) + SO(Q−) + DO(Q+) + DO(Q−)).
By clustering the obtained expression modules based on the similarity of the activity profiles and module overlap, we predicted interacting pairs of TF binding motifs.
While for practical purposes we suggest the use the ProportionalHill method, the most detailed module overlap information is acquirable with the computationally more expensive TotalHill method.
Additional file 6 is a table describing the relevance of the TG module overlap genes to CHD-related traits.
We used a two-tailed Fisher's exact test to determine the significance of the TG module overlap.
Furthermore, we inferred inter-module relations based on module overlap and illustrated the examples of condition-specific co-regulations.
Similar(44)
In additional to simulated annealing, analytical floorplanning approaches have shown their advantage in the effective wire length optimization; however, it is harder to handle the module overlaps and the fixed-outline constraint for such an approach.
Module overlaps might play a key role in the disconnection and synchronization of modules of complex systems, and their re-assembly during and after crisis, respectively.
This may be difficult when a reference module overlaps with several test modules or when the overlaps are small.
Then, we have explored module overlapping and separation effects, and their data-driven or method-driven nature.
The vast majority (93.5%) of the genes in the Mexican TG network module overlapped with the genes in the Finnish twin TG network module.
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