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Based on network analysis, 'party hubs' and 'date hubs' were proposed to understand the basic principle of module organization of biomolecular networks.
Disrupted module organization of basal ganglia-thalamocortical circuit can be one of the key causes of more modules in cirrhotic patients than in controls.
The domain and module organization of this cluster are shown in Figure 3F, which shows the differences from the one for nocobactin synthesis.
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Effective pedagogy needs to include various approaches to learner motivation, module organization, and level of interactivity.
The organization of these interaction networks has been studied using graph-theoretical techniques [ 7- 9] to find global characteristics that can be mapped back to biological phenomena, such as evolutionary conserved interactions, pathway or module organization, and localization of essential proteins in the network, to mention a few.
In a last part, as many enzymes in these pathways display regulatory domains containing the conserved ACT module, the organization of ACT domains in this kind of allosteric enzymes will be reviewed, providing explanations for the variety of allosteric effectors and type of controls observed.
Third, there were no approaches which generated large, comprehensive collections of high-quality modules resulting from exhaustive screens of the modular organization of organisms.
These structural and functional features provide evidence of a hierarchical, module-oriented organization of the HF biomarker-centric network investigated here.
NRPS genes of line #2 were predicted to be for poly-lysine synthesis because their module organizations are the same as that of poly-lysine synthetase (Pls) in Streptomyces albulus[ 37].
Here, we compared the EM structures of the core Mediator and its subcomplex, especially the first 3D structure of the Head + Middle modules, performed nanogold labeling of multiple subunits from different modules, and proposed a new modular organization of Mediator, which resolves many inconsistencies of the previous model with the biochemical and functional studies.
An integrative view of microbial ecology associated with IBD status of individual patients during disease was possible based on the analysis of microbial modules organization [ 19].
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