Our approach is based on the hypothesis that tumors target specific biological modules of critical importance, and that such modules can be algorithmically identified based on network topology alone.
In this methodology, we successively perform the analysis of model nonlinearity, module importance ranking and its evolution with time, module-by-module parameter screening, quantitative analysis of both intra- and inter-module interactions, and the analysis of the complete model with a reduced number of parameters due to parameter screening.
This will be of importance in order to add a dose module for improved individualizing of the GH dose.
A central module of the curriculum should explain the importance of nature conservation and environmental protection and the obligation to comply with the relevant legal stipulations.
The results let us to set design criteria, which account for the Young's module and the importance of an adequate machining and further adjustment of clearances on the shaft-bearing system, thus improving the reliability of such elements.
Indeed, it has been shown that the majority of human kinases contain at least one lipid-binding module, demonstrating the importance of the peripheral protein lipid association in many cellular events.
In mobile M2M communications, the cost and power consumption of an M2M module are of significant importance to draw a comparison between cellular-based and non-cellular-based M2M communication services [6].
One can view the correlation of k.in and essentiality as a test of the modules importance.
Composite materials are a key element in weight reduction strategies, so the analysis of the mechanical behavior of assemblies of composite modules is of great importance.
The fact that signaling pathways that are upregulated by alcohol and over-targeted by upregulated miRNAs also show up enriched in downregulated modules, confirms the importance of these pathways in transducing alcohol's actions during early stages of chronic alcohol consumption and their role as triggers of a miRNA adaptive response aimed at counteracting such activation.
