Sentence examples for module of dna from inspiring English sources
This phenomenon means that ATM works as a memory module of DNA damage.
The overlap of the two modules was four genes with the statistical significance of the p value less than 0.001, considered as the interplay module of DNA methylation and chromatin modifications.
CHMP1A is the differentially methylated gene in the interplay module of DNA methylation and chromatin modifications, and the DNA methylation pattern of this gene was all negatively correlated with that of the connected genes.
Here we have detected the potential interplay modules of DNA methylation and chromatin modifications for T2D.
Using the cumulative hypergeometric test, 24 interplay modules of DNA methylation and chromatin modifications were identified.
In addition, gene modules of DNA metabolism, sulfur metabolism, protein synthesis and aerobic energy metabolism also were identified.
So, the sub-modules with the Bonferroni corrected p value < 0.05 were identified as the interplay modules of DNA methylation and chromatin modifications for T2D.
In the next analysis, the interplay modules of DNA methylation and chromatin modifications for the expression levels of the corresponding genes were investigated.
In the 42 T2D-related DNA methylation modules and 21 T2D-related chromatin modification modules, the interplay modules of DNA methylation and chromatin modifications for T2D were detected by the cumulative hypergeometric test method (see Methods for details).
In summary, in this study, a set of interplay modules of DNA methylation and chromatin modifications was detected, and might play the extremely important roles in the development of T2D.
The module combinations (sub-modules) with the smallest overlap size of 3 were remained, and after the bonferroni multiple testing correction (Bonferroni corrected p value < 0.05), 24 significantly enriched sub-modules were identified and considered as the interplay modules of DNA methylation and chromatin modifications (see Additional file 1).
