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The focal melanocyte regulatory module may reflect the need for co-regulation of two transcription factors.
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Alternatively, the presence of incomplete TA modules may reflect vertically acquired plasmid-associated genes that are in the process of pseudogenization.
In addition, the up-regulation of both complement and major histocompatibility complex I genes (HLA-A/ B/ C genes, and B2M) in the Global Up module, along with APOE elevation in the Retina GA Up and CNV Up modules may reflect activation of resident microglia in the retina [ 134, 135].
The liver-red module also shares genes with the androgen-associated kidney-green module which may reflect the requirement for lipids as precursors in androgen synthesis.
Here, we used an integrative network-based approach for combining multiple large-scale expression studies in blood (2539 individuals) with protein protein Interaction (PPI) data for the detection of consistently coexpressed PPI modules that may reflect key processes that change throughout the course of normative aging.
The different patterns of gene expression for modules in electron transfer systems may reflect differences in rates of nutrient acquisition and incorporation.
Figure 3 shows that genes with H3K4 trimethylation in ES cells contain significantly more black module genes than genes without this marker (Kruskal Wallis test p-value = 6.7 × 10-113) which may reflect the active role the pluripotency module plays in ES cells.
Hence, it seems arguable that the modules of gene expression we have identified may reflect a more complex regulation of cortical maps in gyrencephalic species, instead of patterning folds.
This finding may reflect the preservation of regulatory modules that formed the complex regulatory network of the Hox genes.
Overall, the cholesterol management leaflet tended to score slightly lower which may reflect the different nature of this module.
This decrease may reflect both the decreased number of CohI modules and the decreased levels of this truncated protein, which is not detected by Coomassie blue staining.
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